Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice.

By T. Matoba, H. Shimokawa, M. Nakashima, Y. Hirakawa, Y. Mukai, K. Hirano, H. Kanaide, Akira Takeshita. Journal of Clinical Investigation, 2000

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Endothelial dysfunction and vascular disease – a 30th anniversary update (2017, background): “As predicted (Vanhoutte 2001) following the initial description of the role of H2O2 in EDH (Matoba et al. 2000), the available evidence comforts the interpretation that H2O2 is a physiological signalling molecule serving as an EDH-inducing mediator especially in the microcirculation and thus…”
NADPH Oxidases in Cardiovascular Health and Disease (2006, positive): “Indeed, recent studies suggest that H2O2 released from the endothelium may account for endotheliumderived hyperpolarizing factor (EDHF) vasodilator activity in murine and human mesenteric arteries and in human coronary arterioles, where it is involved in flow-induced dilatation (232, 233, 243, 247).”
Redox signaling in hypertension. (2006, background): “[16] Matoba T, Shimokawa H, Nakashima M, Hirakawa Y, Mukai Y, Hirano K, et al.”
Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “H2O2 has been argued to be an EDHF (395, 749).”
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. (2003, background): “In addition, it has been reported that H2O2 can act as an endothelium-dependent hyperpolarizing factor (57).”