ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.

By Jin Ye, R. B. Rawson, R. Komuro, X. Chen, Utpal P. Davé, R. Prywes, Michael S. Brown, J. Goldstein. Molecules and Cells, 2000

1,882 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8af62ec9a3180cfdeda74c45e8d422a39e3cacc1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Kaufman
2. C. Hetz
3. J. Malhotra
4. Laurie H. Glimcher
5. D. Ron
6. G. Hotamışlıgil
7. Ann-Hwee Lee
8. Peter Walter

In Molecular Biology

1. R. Kaufman
2. C. Hetz
3. Laurie H. Glimcher
4. D. Ron
5. J. Malhotra
6. G. Hotamışlıgil
7. Ann-Hwee Lee
8. Junying Yuan

Citations in the corpus

• The endoplasmic reticulum and the unfolded protein response. (2007, background): “Upon ER stress, CREBH transits to the Golgi compartment where it is cleaved by S1P and S2P processing enzymes.”
• The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. (2010, background): “ATF6 is a transcription factor that is released from the membrane by proteolytic cleavage after ER stress (16).”
• A trip to the ER: coping with stress. (2004, background): “By contrast, the accumulation of unfolded proteins in the ER lumen leads to ATF6 transit to the Golgi complex, where it is cleaved by the proteases S1P and S2P, yielding a free cytoplasmic domain that is an active transcription factor [ 7 ].”
• Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. (2001, background): “…the ER-bound ATF6 transcription factor is required for transcriptional tent with our observation that ire-1 plays the major role in transcriptional activation of the UPR upon ER stress.induction of Xbp1 and to activate the UPR in mammals (Ye et al., 2000; Yoshida et al., 2001b; Lee et al., 2002).”
• The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. (2001, background): “The cleavage of ATF6a is achieved by a two-step process involving site-1 protease (S1P) and site-2 protease (S2P), the same two proteases that process SREBP in response to low cholesterol ( Ye et al., 2001 ).”