Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
By Long N. Nguyen, Dongliang Ma, G. Shui, P. Wong, A. Cazenave-Gassiot, Xiaodong Zhang, Markus R. Wenk, E. Goh, D. Silver. Nature, 2014
930 citations recorded by the source corpus.
Subfields: Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/8ae46867da640c7281ee0d5ca6252659fdeea7f7
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In Physiology
Citations in the corpus
- Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology (2017, background): “Although the mechanisms for DHA uptake into the brain had been enigmatic until recently, MFSD2A has been identified as the major transporter (52), as well as a negative regulator of transcytosis (53).”
- A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity (2020, background): “Major facilitator superfamily Essential omega-3 fatty acids, such as docosahexaenoic acid (DHA), are transported into the brain by the endothelial facilitator superfamily domain-containing protein 2a (MFSD2a) [149].”
- The blood–brain barrier in health and disease: Important unanswered questions (2020, background): “Transport of glucose, lactate, amino acids, and fatty acids occurs via GLUT1 (Slc2a1), MCT1 (Slc16a1), LAT1 (Slc7a5), and MFSD2A, respectively (Boado et al., 1999; Cornford et al., 1994; Kido et al., 2000; Nguyen et al., 2014).”