Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.

By Raymond Habas, Y. Kato, Xi He. Cell, 2001

876 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8ad8b4feeb3dcf4ddbf4c87bd1f6c24cf478685f

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In Molecular Biology

1. Young Chul Kim
2. Henrik Walter
3. K. Guan
4. Fa-Xing Yu
5. I. Dawid
6. H. Varmus
7. Liang Schweizer
8. F. Cong

Citations in the corpus

• A Nucleator Arms Race: Cellular Control of Actin Assembly (2010, background): “and by the phosphoprotein Dishevelled binding to the DA”
• Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. (2003, methodology): “1A,B, 2A,B; Habas et al. 2001).”
• The genetic architecture of the human cerebral cortex (2020, background): “These loci are located near DACT1 and DAAM1, both of which are involved in synapse formation and are key members of theWnt signaling cascade (51, 52).”
• The Hippo pathway: regulators and regulations. (2013, background): “In addition, RhoA is a well-known downstream player of the noncanonical wnt pathway (Habas et al. 2001); thus Fzi/Fmi may regulate YAP/TAZ activity via RhoA and actin organization.”
• Alternative Wnt Signaling Activates YAP/TAZ (2015, background): “Here, we demonstrate the link between PCP components and YAP/TAZ and further show that CELSR2 can also augment FZD-induced YAP/TAZ ble 3T3-L1-Wnt5a cells were treated with Wnt3a (0, 50, and 100 ng/ml) after eatment to compare panels 2 and 6.”
• Targeting cancer stem cell pathways for cancer therapy (2020, background): “127 The small GTPases Rac1 and Rho together trigger ROCK (Rho kinase) and JNK (c-Jun N-terminal kinase).”
• Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation (2003, background): “As noncanonical Wnt signaling has been implicated in the regulation of cytoskeleton rearrangement (Habas et al., 2001), which may cause changes in cell adhesion and migration during mesenchymal condensation, it will be interesting to further investigate whether Wnt-5a also controls chondrocyte…”
• Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled (2004, methodology): “The kinase assays were initiated by the addition of 2 g of GST-Jun(1-109) substrate protein, and 10 Ci of [ -32P]ATP in a volume of 25 l.”