The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium.
By J. Heilborn, M. Nilsson, G. Kratz, G. Weber, O. Sørensen, N. Borregaard, M. Ståhle-Bäckdahl. Journal of Investigative Dermatology, 2003
624 citations recorded by the source corpus.
Subfields: Emergency Medical Services, Immunology, Microbiology
View Paper: https://www.semanticscholar.org/paper/8a9034056323fc146b1f46ff343842d513b4285d
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In Immunology
In Microbiology
Citations in the corpus
- Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1 (2004, background): “CAMP multifunctionality is further underlined by its acceleration of epithelial wound healing (6), suggesting that enhanced antimicrobial peptide expression would protect against infection after surgery and accelerate healing.”
- Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea (2007, result): “Thus, we concluded that the skin of individuals with rosacea, similar to that of individuals with other inflammatory disease”
- Antimicrobial peptides: The ancient arm of the human immune system (2010, background): “High levels of hCAP-18/LL-37 are produced in healing human skin suggesting an important role in re-epithelialization during wound healing.(40) Consistently, healing was inhibited by LL-37 specific antibodies in an organ-cultured human skin model.”
- LL-37, the only human member of the cathelicidin family of antimicrobial peptides. (2006, background): “Downregulation in disease Atopic dermatitis [62,63] Chronic ulcer epithelium [61] Enteric infection [64] Neutrophils, acute myeloid leukemia [105,106]”
- Epithelialization in Wound Healing: A Comprehensive Review (2014, background): “Levels of AMPs increase significantly in early wound healing and subsequently decrease upon wound closure.(133,134) However, expression of AMPs is deregulated in chronic wounds; keratinocytes in nonhealing wounds show a constitutively high baseline expression of human b-defensin-2 (hbD-2) and psoria”
- Cathelicidins, multifunctional peptides of the innate immunity (2004, background): “The precise mechanism of this activity has not been clarified, but lack of immunoreactivity for the proliferation marker Ki67 in the LL-37 antibody-inhibited wound argues for a role of the peptide in the proliferative step [104].”