Pilus retraction powers bacterial twitching motility

By A. Merz, M. So, M. Sheetz. Nature, 2000

859 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8a3a5b524d531a82d70266d6993b8e6113f16acf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. K. Hughes
2. P. Watnick
3. M. Parsek
4. P. Beales
5. M. Givskov
6. E. Karatan
7. D. Dubnau
8. F. Chevance

In Molecular Biology

1. M. Givskov
2. Søren Molin
3. M. Parsek
4. P. Watnick
5. E. Karatan
6. M. Hentzer
7. Inês Chen
8. H. Mobley

Citations in the corpus

• DNA uptake during bacterial transformation (2004, background): “T4P function in bacterial cell-to-cell interactions, adhesion to host cells and twitching motility — a form of locomotion that is powered by extension and retraction of the pilus filamen”
• Type IV pilus structure and bacterial pathogenicity (2004, background): “In spite of their narrow diameter, type IV pili are remarkably strong — capable of withstanding stress forces greater than 100 p”
• Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “Although not all types of pili have been demonstrated to be retractable, many types of pili are able to retract against great force (209, 225, 294).”
• Statistical Analysis of Pseudomonas aeruginosa Biofilm Development: Impact of Mutations in Genes Involved in Twitching Motility, Cell-to-Cell Signaling, and Stationary-Phase Sigma Factor Expression (2002, background): “The mechanical basis for this flagellum-independent type of surface motility is believed to be extension and retraction of the type IV pili, which propel the cells along the surface (19, 35).”
• Coordinating assembly of a bacterial macromolecular machine (2008, background): “Other types of bacterial motility include the extension and retraction of pili to produce twitching motilit”
• Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome (2003, background): “4 ), involved in twitching mobility and type-IV pilus assembl”
• Crystal structures of the pilus retraction motor PilT suggest large domain movements and subunit cooperation drive motility. (2007, background): “Introduction Type IV pili are grappling lines that extend from bacterial cells to solid substrates to be subsequently reeled in by membrane-associated motors, thereby promoting motility on surfaces (Merz et al., 2000;Skerker and Berg, 2001).”
• Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis (2008, background): “ative bacteria (33, 256) and is thought to play a significant role in virulence (128).”