Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics

By D. Suter, Nacho Molina, D. Gatfield, Kim Schneider, U. Schibler, F. Naef. Science, 2011

960 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8a0e1f257369edf06c1572bb81c8fbf20efb8e4f

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In Molecular Biology

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Citations in the corpus

• Single-cell transcriptome sequencing: recent advances and remaining challenges (2016, background): “Growing evidence suggests that genes are not transcribed continuously but rather undergo short bursts of transcription interspersed with silent intervals 95 .”
• Enhancer control of transcriptional bursting (2016, neutral): “Transgeneswere integrated into specific genomic locations via phiC31-mediated transgenesis (Groth et al., 2004; Venken et al., 2006).”
• Molecular Architecture of the Mammalian Circadian Clock (2013, background): “Cis-acting regulatory elements may play a role in shaping the kinetics of transcriptional bursts that contribute to this variability, or noise [85, 86], likely through recruitment and retention of general transcription machinery and co-regulators by factors that remodel the local environment [87], s”
• A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications (2017, background): “For example, at the gene level, transcriptional bursting causes variation in transcript quantities [67], whereas at the global level, the physical size of”
• Quantifying intrinsic and extrinsic noise in gene transcription using the linear noise approximation: An application to single cell data (2013, background): “The Annals of Applied Statistics 2013, Vol. 7, No. 4, 1960–1982 DOI: 10.1214/13-AOAS669 © Institute of Mathematical Statistics, 2013 QUANTIFYING INTRINSIC AND EXTRINSIC NOISE IN GENE”
• Single-Cell and Single-Molecule Analysis of Gene Expression Regulation (2016, background): “For example, chromatin may switch between a permissive and a repressive state, a TF may bind to a promoter or enhancer, or a loop may be formed so that the PIC can reinitiate transcription (26, 38, 136).”