Monitoring of implanted stem cell migration in vivo: A highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat

By M. Hoehn, E. Küstermann, J. Blunk, D. Wiedermann, T. Trapp, S. Wecker, M. Föcking, H. Arnold, J. Hescheler, B. Fleischmann and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

748 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8990fff67cb8e585793023342a4e0e33cc3dbe12

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Duman
2. J. Warner-Schmidt

In Developmental Neuroscience

1. R. Duman
2. J. Warner-Schmidt
3. Fred H. Gage

In Molecular Biology

1. R. Duman
2. J. Warner-Schmidt

Citations in the corpus

• Applications of magnetic nanoparticles in biomedicine (2003, positive): “Dendrimer coatings comprising a highly branched polymer structure that has a high rate of non-cell-specific binding and intracellular uptake have also been used to good effect [135], as has the use of lipofection agents, normally used to carry DNA into the cell nucleus, to enable intracellular incor”
• In vivo imaging platform for tracking immunotherapeutic cells (2005, background): “We note that transfection agents are also effective at delivering SPIO nanoparticles into weakly phagocytic stem cell”
• APPLICATIONS OF MAGNETIC NANOPARTICLES IN BIOMEDICINE (2003, positive): “Dendrimer coatings comprising a highly branched polymer structure that has a high rate of non-cell-specific binding and intracellular uptake have also been used to good effect [135], as has the use of lipofection agents, normally used to carry DNA into the cell nucleus, to enable intracellular incor”
• Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. (2004, background): “response to cerebrovascular ischemia, it is possible that enhanced formation of neovasculature may also be important for survival of embryonic (39) and neural (40) stem cell transplants in other circumstances, such as neurodegenerative disorders.”
• Iron oxide MR contrast agents for molecular and cellular imaging (2004, methodology): “Mouse ES cells were magnetically labeled using a transfection agent and then implanted in the contralateral hemisphere of rats with experimental stroke (using a middle cerebral artery occlusion or MCAO model).(109) In vivo imaging at high field (7 T) and high resolution showed the migration of label”
• Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. (2005, background): “…cells (such as NT2 cells) (Kleppner et al., 1995; Park, 2000), rodent (Sorensen et al., 1996), and human (Barami et al., 2001; Jeong et al., 2003) fetal brain cells and embryonic stem cells (Barami et al., 2001; Hoehn et al., 2002) have been transplanted into the striatum after experimental stroke.”