VEGF is necessary for exercise‐induced adult hippocampal neurogenesis

By K. Fabel, Konstanze Fabel, Betty Y. Y. Tam, D. Kaufer, A. Baiker, Natalie Simmons, C. Kuo, T. Palmer. European Journal of Neuroscience, 2003

871 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/896b7f066ca308644cb990cfd003138897591696

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Wei Deng
2. Hongjun Song
3. Guo-li Ming
4. Gregory D. Clemenson
5. M. Le Moal
6. Fred H. Gage
7. Yaakov Stern

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. Wei Deng
5. E. Gould
6. R. Duman
7. Chunmei Zhao
8. H. van Praag

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. Wei Deng
5. E. Gould
6. Chunmei Zhao
7. R. Duman
8. James Bradley Aimone

Citations in the corpus

• Stress and adult neurogenesis (2006, background): “genesis (van Praag et al., 1999a,b; Fabel et al., 2003; Farmer et al., 2004).”
• Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults (2016, methodology): “Brain-derived neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-I), and vascular endothelial growth factor (VEGF) are currently considered as key proteins that are up-regulated after exercise (Carro et al., 2001; Fabel et al., 2003; Neeper et al., 1995) and that can promote cell prolifer”
• The Influence of Exercise on Cognitive Abilities (2013, positive): “exercise induced neurogenesis and angiogenesis, as corroborated by blocking the effects of exercise using antibodies against IGF-1 (47) or VEGF (63).”
• Exercise is the real polypill. (2013, background): “Current candidate neutrophins mediating exercise-induced neurogenesis are above-mentioned BDNF (231, 533), growth hormone (35), or VEGF (79, 116).”
• Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression (2005, background): “…has shown that adult proliferation takes place near the local microvasculature of the hippocampus (Palmer et al., 2000; Louissaint et al., 2002; Fabel et al., 2003; Yamashima et al., 2004), while both angiogenesis and neurogenesis can be modulated by similar stimuli (Jin et al., 2000; Fabel et…”
• The effects of exercise and stress on the survival and maturation of adult-generated granule cells (2009, positive): “Alternative candidates for mediating survival during this early period include VEGF and IGF-I, which are required for running effects on neurogenesis (Trejo et al., 2001; Fabel et al., 2003), and BDNF, which is increased by running and has been suggested as a mediator of its effects on synaptic plas”
• Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Two factors identified from these studies are insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF), both of which were shown to be necessary in mediating the exercise-induced increase of neurogenesis (Trejo et al., 2001; Fabel et al., 2003).”
• Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. (2006, background): “…forebrain neural stem cells and demonstrate that secreted factors from endothelial cells also promote neural stem cell proliferation (Cao et al., 2004; Fabel et al., 2003; Jin et al., 2002; Maurer et al., 2003; Schanzer et al., 2004; Shen et al., 2004; Yasuhara et al., 2004; Zhu et al., 2003).”
• Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, background): “VEGF is also required for the induction of neurogenesis in response to exercise (Fabel et al., 2003).”
• Adult neurogenesis: from precursors to network and physiology. (2005, background): “This is supported by the observation that icv administration of VEGF (0.24 ␮g/day for 3 days concurrent with 2 ϫ 50 mg · kg Ϫ1 · day Ϫ1 BrdU) stimulates cell proliferation in the rodent SVZ and SGZ by 7 days after treatment onset (241).”