Nodal signaling in vertebrate development.

By A. Schier. Annual Review of Cell and Developmental Biology, 2003

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Smad transcription factors. (2005, methodology): “For more information on the biology of the TGF family, we would recommend several classical reviews (Letterio and Roberts 1998; Whitman 1998; Massagué and Chen 2000; Massagué et al. 2000; Derynck et al. 2001; Attisano and Wrana 2002; Schier 2003).”
Tensile forces govern germ-layer organization in zebrafish (2008, background): “Nodal/TGFβ signalling is known to be required and sufficient to induce mesoderm and endoderm cell fates and morphogenesi”
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, background): “, 2006), consistent with increased Nodal signaling required for definitive endoderm formation in the early embryo (Schier, 2003).”
TGFβ–SMAD signal transduction: molecular specificity and functional flexibility (2007, background): “Nodal, similar to other ligands such as GDF3 and GDF1 (also known as Vg1), strictly depends on the presence of EGF-CFC co-receptors to signal, whereas activin can signal without co-receptor”
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells (2005, methodology): “Although the canonical effect of Nodal signalling in vertebrate development is induction of mesoderm and endoderm differentiation (Schier, 2003), several mutations associated with Nodal signalling lead to decreased proliferation of the epiblast (Conlon et al., 1991; Dunn et al., 2004; Gu et al.,…”