Aerobic exercise training increases brain volume in aging humans.

By Stanley J. Colcombe, Kirk I. Erickson, Paige E. Scalf, Jennifer S. Kim, Ruchika Shaurya Prakash, E. McAuley, S. Elavsky, D. Marquez, Liang Hu, A. Kramer. The journals of gerontology. Series A, Biological sciences and medical sciences, 2006

2,157 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/2f6960ab521e3303a7595c2d12fa5e521373fb8e

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Citations in the corpus

Physical Activity, Fitness, Cognitive Function, and Academic Achievement in Children: A Systematic Review. (2016, background): “exercise alters specific brain structures and functions and the changes were associated with older adults' cognitive performance (40, 41, 101), particularly on tests requiring greater amounts of executive functions (EF), which describes a subset of goal-directed cognitive operations underlying perce”
Aging, training, and the brain: A review and future directions (2009, neutral): “An absence of reported training-induced overactivation is even more surprising given that several structural imaging studies have reported that older adults show increases in volume in regions where young adults do not (Boyke et al. 2008; Colcombe et al. 2006).”
Exercise training increases size of hippocampus and improves memory (2011, background): “Aerobic exercise training increases gray and white matter volume in the prefrontal cortex (9) of older adults and increases the functioning of key nodes in the executive control network (10, 11).”
Harnessing neuroplasticity for clinical applications (2011, positive): “…ageing and early dementia, may be of benefit in schizophrenia (Colcombe et al., 2004; Kramer and Erickson, 2007), and have been shown to increase brain volume in a variety of regions (Colcombe et al., 2006; Pajonk et al., 2010) and to enhance brain network functioning (Colcombe et al., 2004).”
Aerobic Fitness is Associated With Hippocampal Volume in Elderly Humans (2009, neutral): “Aerobic exercise interventions have been found to reverse decay in prefrontal and lateral temporal regions (Colcombe et al., 2006), and cardiorespiratory fitness levels moderate agerelated declines in volume of the prefrontal and parietal regions (Colcombe et al., 2003).”
Effects of Physical Activity on Children’s Executive Function: Contributions of Experimental Research on Aerobic Exercise (2010, background): “Further support that aerobic exercise promotes morphological changes in humans comes from a randomized controlled trial conducted by Colcombe and colleagues (Colcombe et al., 2006).”
Exercise and Physical Activity for Older Adults (2020, positive): “The mechanism for the relationship between physical activity and exercise and cognitive functioning is not well understood; however, several researchers have suggested that enhanced blood flow, increased brain volume, elevations in brain-derived neurotrophic factor, and improvements in neurotransmit”
Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function. (2007, methodology): “More recently, Colcombe et al. [ 28 ] employed a semi-automated segmentation technique on high-resolution MRI data from older adults who were randomly assigned to either six months of an exercise intervention or a stretching and toning, nonaerobic control group.”
Positive effect of acute mild exercise on executive function via arousal-related prefrontal activations: An fNIRS study (2014, background): “Recent studies have shown that chronic exercise can not only lead to structural changes of the brain (Colcombe et al., 2006; Erickson et al., 2011; Hillman et al., 2008), but also lower the risks of age-related cognitive decline and neurological diseases later in life (Lautenschlager et al., 2008;…”
Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study—Revisited (2018, background): “For example, we (Colcombe et al., 2006) examined the effects of a 6-month aerobic training program (walking) on changes in regional brain volume of 59 healthy but sedentary older adults.”
The Influence of Exercise on Cognitive Abilities (2013, neutral): “Twenty younger adults were also included to assess changes in brain structure over the course of a 6-month period, but did not participate in an exercise intervention Results indicated that brain volume increased for both adult comprising the control group (32).”
Motor control and aging: links to age-related brain structural, functional, and biochemical effects. (2010, positive): “In addition, Colcombe et al. (2006) showed older adults with higher cardiovascular fitness levels are better at activating attentional resources, including decreased activation of the anterior cingulate cortex.”