Plzf is required in adult male germ cells for stem cell self-renewal

By F. W. Buaas, A. Kirsh, Manju Sharma, D. Mclean, Jamie L Morris, M. Griswold, D. D. de Rooij, R. Braun. Nature Genetics, 2004

876 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Essential role of Plzf in maintenance of spermatogonial stem cells (2004, result): “Our findings are in agreement with the observations that a Zfp145 -inactivating mutation is found in the luxoid mutant, a mouse strain that has impaired spermatogenesis and progressive loss of spermatogoni”
Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis (2018, neutral): “3B and C) (Buaas et al., 2004; Lolicato et al., 2008).”
Spermatogenesis: The Commitment to Meiosis. (2016, background): “ZBTB16, a transcriptional repressor expressed in A spermatogonia (10), is coexpressed with OCT4 and regulates the epigenetic state of undifferentiated cells (10, 22).”
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. (2007, methodology): “Spermatogenic failure and germ cell loss can result from defects in germ cells or in their somatic environment ( Brinster, 2002 ).”
The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage (2008, methodology): “C3-Zbtb16Lu/J) mice were obtained from The Jackson Laboratory and have been described elsewhere (Buaas et al., 2004).”