Essential role of Plzf in maintenance of spermatogonial stem cells
By J. Costoya, R. Hobbs, M. Barna, G. Cattoretti, K. Manova, M. Sukhwani, K. Orwig, D. Wolgemuth, P. Pandolfi. Nature Genetics, 2004
932 citations recorded by the source corpus.
Subfields: Genetics, Public Health, Environmental and Occupational Health, Reproductive Medicine
View Paper: https://www.semanticscholar.org/paper/fdbf522d6a92cbb19410ae974a62e45837e2fe5e
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In Genetics
Citations in the corpus
- Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. (2008, background): “One such candidate factor is PLZF, a zinc-finger protein involved in self-renewal of adult male germ stem cells (Buaas et al. 2004; Costoya et al. 2004) and highly expressed in multipotent hematopoietic precursors (Reid et al.”
- The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage (2008, background): “Instead, lack of PLZF in the Luxoid mouse or in a targeted knockout resulted in the progressive loss of spermatogonial stem cells (Buaas et al., 2004; Costoya et al., 2004), suggesting a role of PLZF in regulating cellular proliferation and differentiation.”
- Spermatogenesis: The Commitment to Meiosis. (2016, background): “ZBTB16, a transcriptional repressor expressed in A spermatogonia (10), is coexpressed with OCT4 and regulates the epigenetic state of undifferentiated cells (10, 22).”