Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.

By H. Overton, A. J. Babbs, S. Doel, M. Fyfe, Lisa S Gardner, Graeme Griffin, H. Jackson, M. J. Procter, C. Rasamison, Mads Tang-Christensen and 3 more. Cell Metabolism, 2006

655 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/88535bffa6755b6816df14755c5988c44e2d0112

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In Endocrinology, Diabetes and Metabolism

1. Juan José Marín-Peñalver
2. Cristina Sevillano-Collantes
3. Iciar Martín-Timón
4. F. J. del Cañizo-Gómez

In Pharmacology

1. R. Pertwee
2. V. Di Marzo
3. George Kunos
4. R. Ross
5. R. Mechoulam
6. K. Mackie
7. Allyn C. Howlett
8. P. Greasley

In Surgery

1. Johan Auwerx
2. George Kunos
3. R. Pertwee
4. V. Di Marzo
5. J. Y. Chiang

Citations in the corpus

• The G protein-coupled receptor subset of the rat genome (2007, methodology): “These were systematically searched using keyword look-ups in Pubmed and BLAST in the NCBI's non-redundant (nr) database to find receptor deorphanization reports [26,76-85].”
• International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, background): “Because only N -oleoyl dopamine and oleoyl ethanolamide have reasonably high (low micromolar) affinity for GPR119, and because neither of these lipids interacts with CB 1 or CB 2 receptors, GPR119 cannot be viewed as a cannabinoid receptor.”
• TGR5-mediated bile acid sensing controls glucose homeostasis. (2009, background): “…demonstrate that GLP-1producing enteroendocrine cells are sensitive not only to nutrients present in the intestinal lumen, such as glucose and lipids (Edfalk et al., 2008; Hirasawa et al., 2005; Overton et al., 2006; Reimann et al., 2008), but also to BAs, that activate the TGR5 signaling pathway.”
• Update on the treatment of type 2 diabetes mellitus. (2016, background): “G protein-coupled receptor 119 (GPR119) agonists is a G protein-coupled receptor that is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents [361] .”