Does oxidative damage to DNA increase with age?

By Michelle L. Hamilton, H. Van Remmen, Jessica A. Drake, Hong Yang, Zhongmao Guo, Kristen Kewitt, C. Walter, A. Richardson. Proceedings of the National Academy of Sciences of the United States of America, 2001

791 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/87eb9a2e96f7a97ee95f6d9ebf0fd4493207819c

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Citations in the corpus

The evolution of senescence from a comparative perspective (2008, background): “Organisms accumulate damage with age (Hamilton et al. 2001; Tahara, Matsuo & Kaneko 2001; Judge et al. 2005; Mansouri et al. 2006) and the cost of controlling the effects of this damage must increase exponentially because of synergistic interactions of this damage on individual survival.”
Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-related Hearing Loss under Caloric Restriction (2010, background): “It is well established that CR reduces oxidative damage to DNA, proteins, and lipids in multiple tissues in mammals (Sohal and Weindruch, 1996; Masoro, 2000; Hamilton et al., 2001).”
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “In the case of DNA, oxidative damage to mitochondrial and nuclear nucleic acids is significantly increased in all major tissues in aged organisms, including mice (93), rats (93, 269), hamsters (255), and humans (79, 241).”
Oxidative DNA damage: mechanisms, mutation, and disease (2003, background): “(173) noted age-related increases in 8-OH-dG in nuclear and mitochondrial DNA derived from a variety of rats organs, concluding this to derive from a tissue’s increased sensitivity to oxidative damage, rather than decreased repair.”
Cellular senescence in cancer and aging. (2007, positive): “Organismal aging is accompanied by significant increases in DNA mutations (Vijg, 2000), DNA oxidation (Hamilton et al., 2001), chromosome losses (Rehen et al., 2005; Weaver et al., 2007), and telomereindependent γH2AX foci (Sedelnikova et al., 2004).”
Trends in oxidative aging theories. (2007, background): “The majority of studies verified the first aspect of Harman's hypothesis: that oxidative damage increases during aging (e.g., [17] [18] [19], reviewed in [19] [20] [21]).”
Exercise, oxidative stress and hormesis. (2008, neutral): “…training are necessary to significantly improve endothelium-dependent vasodilation in healthy young man (Clarkson et al., 1999), while for patients with depressed NO bioactivity, even 4 weeks of training is beneficial (Hambrecht et al., 2000a,b; Hamilton et al., 2001; Hambrecht et al., 2000).”
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. (2003, background): “, increased levels of 8oxodG, is of particular interest because 8oxodG is known to be a premutagenic lesion in mammalian cells, which could play a role in the initiation of cancer (17), and because an agerelated increase in 8oxodG is a universal phenomenon in rodents (10) that has been proposed to b”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “Dietary restriction will inhibit the accumulation of both forms of mtDNA damage (67, 139).”