Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells

By M. Lewin, N. Carlesso, C. Tung, Xiao-Wu Tang, D. Cory, D. Scadden, Ralph Weissleder. Nature Biotechnology, 2000

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Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating. (2003, background): “Some authors [12,10] performed the graft, on a crosslinked dextrancoated superparamagnetic nanoparticles, of a membrane translocating signal peptide, (namely the HIV-1 Tat protein, known to freely travel through cellular and nucleic membranes) and succeeded in improving the magnetic labeling efficie”
Synthesis and applications of nano-structured iron oxides/hydroxides - a review (2011, methodology): “…monoclonal antibody, modification of USPIO (ultra small super paramagnetic iron oxide) or MION (mono crystalline iron oxide nanoparticles) with tat-proteins facilitating the incorporation into the cells (Häfeli et al., 1997; Josephson et al., 1999; Lewin et al., 2000; Bulte et al., 2001).”
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. (2005, background): “targeting to cell [222,247] Phosphorylcholine Poorly complement and coagulation activating, colloidal solution stabilizer [91] Poly (D, L- lactide) Biocompatible, low cytotoxicity [85] Poly(N-isopropylacrylamide) (PolyNIPAAM) Thermosensitive drug delivery and cell separation [252]”