Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.

By J. Pin, T. Galvez, L. Prézeau. 2003

650 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Nutrition and Dietetics

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Citations in the corpus

GPCRdb in 2021: integrating GPCR sequence, structure and function (2020, methodology): “The generic residue numbering uses a structural investigation to confirm or correct the receptor residue that corresponds to the reference position (designated the number 50) in each of TM1–7 using the sequence-based numbering scheme for the given GPCR class (A: BallesterosWeinstein (13), B1: Wootte”
Heterotrimeric G protein activation by G-protein-coupled receptors (2008, background): “Dimerization has also been demonstrated in glutamate family receptors; in particular, the γ-aminobutyric acid type B (GABA B ) receptor was one of the first GPCRs shown to function as a heterodime”
Maximum Entropy Reconstructions of Dynamic Signaling Networks from Quantitative Proteomics Data (2009, background): “GPCR5C is a tissue specific, G-protein coupled receptor[27].”
The activation mechanism of class-C G-protein coupled receptors (2004, background): “Class-C GPCRs include the receptors for the two main neurotransmitters, glutamate and GABA, the receptor for Ca and Mg and a number of receptors found in the vomeronasal organ and likely responsible for pheromone detection (Pin et al., 2003).”
Metabotropic glutamate receptors: From the workbench to the bedside (2010, background): “Lastly, as observed in other GPCRs, both the intracellular loops 2 and 3, as well as the helix 8 are important in G-protein coupling, being also involved in coupling selectivity (Pin et al., 2003).”
The Statistical Trends of Protein Evolution: A Lesson from AlphaFold Database (2022, neutral): “…elaborating on the phylogenetic analysis of pro-teomes (Gerstein et al. 1994; Caetano-Anollés et al. 2009, 2021) or the proteins that share the common ancestral sequence or structure (Labas et al. 2002; Pin et al. 2003; Zardoya 2005; Morcos et al. 2011; Finnigan et al. 2012; Espada et al. 2015).”
A Structural Framework for GPCR Chemogenomics: What's In a Residue Number? (2018, methodology): “GPCR Classes Numbering schemes using a similar logic to the BW numbering have later been proposed by Wootten for class B [58], Pin for class C [59], and Wang for class F GPCRs [19].”
Generic GPCR Residue Numbers - Aligning Topology Maps Minding The Gaps (2014, methodology): “The class C GPCR Pin [24] numbering was used in the publication of the metabotropic glutamate receptor 5 (mGlu 5 ) crystal structure [25].”
Ionotropic and metabotropic glutamate receptor structure and pharmacology (2005, neutral): “10) (Bhave et al. 2003; Pin et al. 2003).”