Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.

By Katherine Jakubs, Avtandil Nanobashvili, S. Bonde, Christine T. Ekdahl, Z. Kokaia, M. Kokaia, O. Lindvall. 2006

271 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “, 1997), and altered electrophysiological properties of GABAergic and glutamatergic synaptic inputs for newborn granule cells (Jakubs et al., 2006).”
The Developmental Stage of Dentate Granule Cells Dictates Their Contribution to Seizure-Induced Plasticity (2010, background): “Adult-born DGCs integrating after SE appear to have complex influences, as recordings from RV-GFP-labeled DGCs in the granular layer after electrically induced SE suggest that they show reduced excitability (Jakubs et al., 2006).”
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “…to hippocampal dysfunction observed in neuropsychiatric diseases such as cognitive decline during aging (Kuhn et al., 1996; Drapeau et al., 2003), anxiety and depression (Bergami et al., 2008; Revest et al., 2009), and epilepsy (Jessberger et al., 2005; Jakubs et al., 2006; Parent et al., 2006).”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, methodology): “Immunofluorescent triple labeling was done as described previously (Jessberger and Kempermann, 2003).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “Adult hippocampal neurogenesis may represent a candidate target process for the treatment of age-related cognitive decline (Drapeau and Nora Abrous, 2008), seizure-induced cognitive impairment (Jakubs et al., 2006; Jessberger et al., 2007), and mood disorders (Duman, 2004; Sahay and Hen, 2008).”
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, unknown): “…secretion of BDNF protein has been associated with cognitive and structural abnormalities of the CNS (Egan et al., 2003; Pezawas et al., 2004), though consensus is lacking on its influence on susceptibility to mood disorders (Choi et al., 2006; Jiang et al., 2005; Schule et al., 2006).”
Adult hippocampal neurogenesis in depression (2007, background): “, whereas status epilepticus induced by stimulation of the ventral hippocampus causes reduced excitatory synaptic input and increased inhibitory drive in new neuron”
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling (2007, background): “In that study, Jakubs et al. (2006) found increased inhibitory and reduced excitatory input onto granule cells born after SE compared with granule cells generated in the running animals.”