EPIGENETIC TRANSGENERATIONAL ACTIONS OF ENVIRONMENTAL FACTORS IN DISEASE ETIOLOGY
By Michael K. Skinner, M. Manikkam, Carlos Guerrero-Bosagna. Trends in endocrinology and metabolism, 2010
701 citations recorded by the source corpus.
The ability of environmental factors to promote a phenotype or disease state not only in the individual exposed but also in subsequent progeny for multiple generations is termed transgenerational inheritance. The majority of environmental factors such as nutrition or toxicants such as endocrine disruptors do not promote genetic mutations or alterations in DNA sequence. In contrast, these factors have the capacity to alter the epigenome. Epimutations in the germ line that become permanently programmed can allow transmission of epigenetic transgenerational phenotypes. This review provides an overview of the epigenetics and biology of how environmental factors can promote transgenerational phenotypes and disease.
Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/86a8ed3b837baaf42043d2e77083f48097278434
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- Carlos Guerrero-Bosagna
- M. Manikkam
- B. Pujol
- A. Pocheville
- S. Blanchet
- Etienne G. J. Danchin
- Eva Jablonka
In Molecular Biology
- Carlos Guerrero-Bosagna
- M. Manikkam
- J. Zambonino-Infante
- B. Pujol
- A. Pocheville
- B. Blumberg
- Michael K. Skinner
- S. Blanchet
In Pediatrics, Perinatology and Child Health
Citations in the corpus
- Epigenetically facilitated mutational assimilation: epigenetics as a hub within the inclusive evolutionary synthesis (2018, background): “2), parent–offspring resemblance results from the simultaneous exposure of the pregnant female (hereafter exposed individuals are defined as the F0 generation) and its developing embryos (F1) (Skinner & Anway, 2005; Skinner et al., 2010; Heard & Martienssen, 2014) to a common environmental factor.”
- Fantastically plastic: fish larvae equipped for a new world (2013, background): “A key distinction is that epigenetic effects produce heritable traits which can be found over either several rounds of cell division or even to the next generation of the organism (Skinner et al. 2010).”
- Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations (2013, background): “This modification of germline epigenetic programming occurs during the gonadal sex determination period when the germline DNA is demethylated and remethylated in a sex specific manner [1,5].”
- Endocrine Disrupting Chemicals and Disease Susceptibility (2011, background): “However, in some cases these environmental factors promote a heritable transmission of the disease phenotype through successive generations [5, 56, 61].”
- Effects of Late Gestational High Fat Diet on Body Weight, Metabolic Regulation and Adipokine Expression in Offspring (2013, positive): “These assumptions have been corroborated significantly by studies involving prenatal stress (2-4) and induced maternal malnutrition (5).”
- Child health, developmental plasticity, and epigenetic programming. (2011, background): “This altered program and gene expression profile can then promote an abnormal physiology and disease at the later adult stage of development (167).”