A loss-of-function RNA interference screen for molecular targets in cancer
By Louis M. Staudt. Nature, 2006
647 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/864ffd59eae09e0a1096af78c748099cbd5f4894
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In Molecular Biology
- David M. Sabatini
- M. Karin
- Eric S. Lander
- David E. Hill
- Joseph A. DiDonato
- Tim Wang
- F. Mercurio
- W. Kuehl
Citations in the corpus
- Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. (2007, methodology): “NIK Overexpression Activates NF-kB Signaling and Blocks Cell Death in MM To examine the functional significance of NIK overexpression in myeloma cell lines, we designed short hairpin RNAs (shRNAs) targeting NIK and expressed them in cell lines in an inducible fashion using retroviruses (Ngo et al., ”
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, neutral): “The second approach takes a more functional, systemsbiology approach to identify cancer cell vulnerabilities (Ngo et al., 2006; Schlabach et al., 2008; Silva et al., 2008 RNAi-mediated protein knockdown results in either partial or complete loss of function, which in many cases closely mimics the…”
- 30 years of NF-κB: a blossoming of relevance to human pathobiology (2017, neutral): “CARD11 missense mutations are found in 9.6% of DLBCL tumor biopsies.”
- Integrative genomic approaches identify IKBKE as a breast cancer oncogene. (2007, background): “, 2004), including those necessary for cancer cell viability (Moffat et al., 2006; Ngo et al., 2006).”
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System (2013, methodology): “The target sequences (each encoded by a vector of 80 binary variables representing the presence or absence of each nucleotide (A, C, T, G) at each position (1-20) along the target sequence) of ribosomal protein gene-targeting sgRNAs were used as inputs to the classifier which was trained on the chan”
- Mutations of multiple genes cause deregulation of NF-kB in diffuse large B-cell lymphoma (2009, neutral): “ABC-DLBCL Non-GC/NC-DLBCL Biallelic deletion Mutation plus deletion Biallelic mutation Heterozygous mutation Monoallelic deletion Normal Mutated Deleted Normal Nonsense mutations (12) Frameshift deletions (7) Frameshift insertions (5) Splice site mutations (2)”