The cancer genome

By Michael R. Stratton, Peter J. Campbell, P. Futreal. Nature, 2009

3,642 citations recorded by the source corpus.

All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/8627fab9ddf3fae75bc18a705c4904dac66ff9ab

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Citations in the corpus

The Life History of 21 Breast Cancers (2012, background): “Somatic mutation is the fundamental mechanism by which cancer cells suborn these pathways (Stratton et al., 2009), notwithstanding the contributions of epigenetic changes, cues from the local microenvironment and germline genetic variation.”
The DNA-damage response in human biology and disease (2009, background): “A fundamental feature of cancer is genome instability 60 .”
Guidelines for the welfare and use of animals in cancer research (2010, background): “Over the last decade there has been an extraordinary increase in our knowledge of the fundamental molecular processes that are involved in the development of cancer and its response to treatment (Hanahan and Weinberg, 2000; Vogelstein and Kinzler, 2004; Stratton et al, 2009).”
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia (2011, background): “The development of massively parallel sequencing technologies makes it feasible to catalog all classes of somatically acquired mutations in a cance”
Integrated Omics: Tools, Advances, and Future Approaches. (2019, background): “The Cancer Genome Atlas (TCGA, https://tcgadata.nci.nih. gov/tcga/) has been generating multimodal genomics, epigenomics and proteomics data for thousands of tumor samples from >20 types of cancers (Tomczak et al. 2015).”
Mut2Vec: distributed representation of cancerous mutations (2018, background): “Cancer cells are due to their accumulated mutations that occurred during their evolutionary process [16].”
Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor (2020, neutral): “The somatic mutations found in a cancer genome are the cumulative result of all endogenous and exogenous mutational processes that have been operative through the lineage of a cancer cell.(1) By examining the types of mutations in TP53 across cancers, early studies demonstrated that specific environ”