Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors
By Prashanth Rawla, T. Sunkara, V. Gaduputi. World Journal of Oncology, 2019
1,940 citations recorded by the source corpus.
Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide. However, its toll is higher in more developed countries. Reasons for vast differences in mortality rates of pancreatic cancer are not completely clear yet, but it may be due to lack of appropriate diagnosis, treatment and cataloging of cancer cases. Because patients seldom exhibit symptoms until an advanced stage of the disease, pancreatic cancer remains one of the most lethal malignant neoplasms that caused 432,242 new deaths in 2018 (GLOBOCAN 2018 estimates). Globally, 458,918 new cases of pancreatic cancer have been reported in 2018, and 355,317 new cases are estimated to occur until 2040. Despite advancements in the detection and management of pancreatic cancer, the 5-year survival rate still stands at 9% only. To date, the causes of pancreatic carcinoma are still insufficiently known, although certain risk factors have been identified, such as tobacco smoking, diabetes mellitus, obesity, dietary factors, alcohol abuse, age, ethnicity, family history and genetic factors, Helicobacter pylori infection, non-O blood group and chronic pancreatitis. In general population, screening of large groups is not considered useful to detect the disease at its early stage, although newer techniques and the screening of tightly targeted groups (especially of those with family history), are being evaluated. Primary prevention is considered of utmost importance. Up-to-date statistics on pancreatic cancer occurrence and outcome along with a better understanding of the etiology and identifying the causative risk factors are essential for the primary prevention of this disease.
Subfields: Epidemiology, Oncology, Surgery
View Paper: https://www.semanticscholar.org/paper/3baf83b793164e91f697f3b75434ca5f9b10eb63
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Citations in the corpus
- Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer (2019, neutral): “Arthralgia 14 (15) 1 (1) 6 (10) 0 5 (−7 to 16) 1 (−5 to 6)”
- PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance (2020, background): “Pancreatic Cancer Pancreatic cancer is recognized to be one of the most common cause of cancer-associated deaths worldwide, with the 5year survival rate being a mere 9% (Rawla et al., 2019).”
- The impact of pre- and post-image processing techniques on deep learning frameworks: A comprehensive review for digital pathology image analysis (2020, background): “Prostate cancer (PCa) is the most common cancer in men and the fifth cause of cancer-related death globally [101,102].”