Determination of left–right patterning of the mouse embryo by artificial nodal flow

By S. Nonaka, Hidetaka Shiratori, Y. Saijoh, H. Hamada. Nature, 2002

702 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/85dfdf5fe150a2f81fa6cf53fdd8fa2482542235

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Citations in the corpus

Frontiers of chaotic advection (2014, background): “, 2016); and they are fundamental for defining our vertebrate body plan by breaking the left-right symmetry of the early embryo (Nonaka et al., 2002; Cartwright, Piro, and Tuval, 2004; Cartwright et al., 2007; Supatto, Fraser, andVermot, 2008;Montenegro-Johnson et al., 2012; Smith et al., 2012).”
Biological Physics of the Developing Embryo (2005, neutral): “, anticlockwise) fluid currents (nodal flow) that bias the distribution of nodal and thus determine the polarity of the broken symmetry (Nonaka et al., 2002).”
Mechanical control of tissue and organ development (2010, background): “Cell distortion induced either by cell migration or fluid flow has been suggested to trigger the initial left-right (L/R) body plan symmetry-breaking event that takes place in the node of the primitive streak in chicks (Gros et al., 2009) and mice (Nonaka et al., 2002; Tanaka et al., 2005).”
Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut (2005, background): “1247”
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis (2005, background): “Artificial reversal of nodal flow has been shown to randomize the left-right axis, providing further support for the ‘nodal flow’ hypothesis (Nonaka et al., 2002).”
Forces in tissue morphogenesis and patterning. (2013, positive): “The unidirectional flow above the surface is thought to asymmetrically distribute not-yet-identified signaling molecules (Tabin and Vogan, 2003) along the LR axis of the organ that subsequently polarizes the embryo along this axis (Nonaka et al., 2002; Okada et al., 2005).”
TRP channels as cellular sensors (2003, background): “Motile monocilia generate nodal flow, and non-motile TRPP2-containing cilia sense nodal flow, initiating an asymmetric Ca 2p signal at the left nodal borde”