Cardiac troponin T is essential in sarcomere assembly and cardiac contractility
By Amy J. Sehnert, Anja Huq, B. Weinstein, C. Walker, M. Fishman, D. Stainier. Nature Genetics, 2002
615 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine
View Paper: https://www.semanticscholar.org/paper/84f47efbefa0320da83157e45205185b53d84099
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- J. Incardona
- A. Hill
- Morteza Gharib
- T. Collier
- D. Stainier
- H. Teraoka
- Suk-Won Jin
- W. Heideman
Citations in the corpus
- Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons. (2004, background): “The morpholino oligonucleotide (5V-CATGTTTGCTCTGATCTGACACGCA3V; GeneTools, Philomath, OR) spans the cardiac troponin T translation start site and flanking 5V sequence (Sehnert et al., 2002).”
- Cellular and molecular analyses of vascular tube and lumen formation in zebrafish (2005, methodology): “Embryos were treated with 1.5 M of the Vegfr antagonist SU5416 (Calbiochem) as previously described (Fong et al., 1999; Serbedzija et al., 1999).”
- Zebrafish as a model vertebrate for investigating chemical toxicity. (2005, background): “…al., 1996; Xu et al., 2002); silent heart has no heartbeat, with a mutation in the gene tnnt2, also involved in cardiomyopathy (Chen et al., 1996; Sehnert et al., 2002); and heartstrings has differentiation defects with a mutation in the tbx5 gene found in Holt-Oram syndrome (Garrity et al.,…”
- Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis (2003, background): “For example, silent heart mutant embryos establish gut peristalsis and are able to hatch and swi”
- Zebrafish as a model to study cardiac development and human cardiac disease (2011, background): “Positional cloning of two sil alleles revealed inactivating mutations in the tnnt2 gene encoding cardiac troponin T.(71) Mutations in human TNNT2 cause DCM and familial HCM, the leading cause of sudden death in young athletes, making the sil/tnnt2 mutant an excellent model to study the role of Tnnt2”