HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
By Zoltan Arany, S. Foo, Yanhong Ma, J. Ruas, A. Bommi-Reddy, G. Girnun, M. Cooper, Dina Laznik, Jessica Chinsomboon, S. Rangwala and 3 more. Nature, 2008
1,096 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/84e92a9ddbf9bcea0e2d6255353246249c0b47d0
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Molecular Biology
- Jiandie D. Lin
- B. Spiegelman
- A. Suomalainen
- Jun Wu
- Michael E. Greenberg
- J. Nunnari
- J. Wargo
- Christoph Handschin
In Physiology
- B. Spiegelman
- Jiandie D. Lin
- Jun Wu
- Dina Laznik-Bogoslavski
- Di Ma
- A. Suomalainen
- Michael E. Greenberg
- J. Nunnari
Citations in the corpus
- Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway (2013, background): “…because exercise is known to change the metabolic state of the whole body, another important factor could be changes in the energy state or oxygen levels within the brain, both signals to which Pgc1a gene expression is known to respond in other tissues (Arany et al., 2008; St-Pierre et al., 2006).”
- Mitochondria: In Sickness and in Health (2012, background): “The regulation of mitochondrial biogenesis is tightly coordinated with pathways that induce vascularization, enhance oxygen delivery to tissues, and enable oxygen supply to facilitate efficient mitochondrial oxidization of glucose and fat (Arany et al., 2008).”
- Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF (2013, positive): “PGC1a mRNA expression is sensitive to numerous signaling inputs that have been implicated in cancer biology (Herzig et al., 2001; Yoon et al., 2001; Chinsomboon et al., 2009; Arany et al., 2008).”
- Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging (2009, background): “The increased blood supply contributes to the improved muscular function (26) as well as improved muscle metabolism as previously reported (27).”