IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

By M. Hu, Dung‐Fang Lee, W. Xia, L. Golfman, Ou-Yang Fu, Jer-Yen Yang, Y. Zou, Shilai Bao, N. Hanada, H. Saso and 2 more. Cell, 2004

629 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/84dedb202b5c48e886d7e4b713b4ec3c7e3b2595

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1. Joseph A. DiDonato
2. F. Mercurio
3. R. Gomis
4. J. Massagué
5. M. Karin
6. Guri Tzivion
7. M. Dobson
8. Yi Yang

Citations in the corpus

• Deubiquitination and Stabilization of PD-L1 by CSN5 (2016, background): “, 2012), proliferation (Hu et al., 2004), angiogenesis (Lee et al.”
• A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, unknown): “In a similar vein, the role of FOXOs in pathological states including cancer and diabetes mellitus (Hu et al., 2004; Nakae et al., 2002) points to the possibility that misregulation of MST-FOXO signaling might contribute to the pathogenesis of these disorders.”
• Good cop, bad cop: the different faces of NF-κB (2006, unknown): “These include phosphorylation of histone H3 by IKKa,(11) IKKa phosphorylation of the SMRT corepressor(32) as well as estrogen receptor a and its coactivator SRC-3/ AIB1,(33) IKKb phosphorylation of 14-3-3b(34) and Dok1,(35) and IKKb phosphorylation of the Forkhead transcription factor FOXO3a.(36) In”
• NF‐κB and the link between inflammation and cancer (2012, background): “Hu MC, et al. IkappaB kinase promotes tumorigenesis through inhibition of fork- head FOXO3a.”
• The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes (2016, unknown): “Low expression of these two genes has been previously linked with poor outcome in breast cancer 26,27 .”
• Redox regulation of FoxO transcription factors (2015, unknown): “Other IKKβ S644 [325] FoxO3a: inactivation, nuclear exclusion, degradation↑ [325]”
• The logic of TGFβ signaling (2006, background): “For instance, FoxO factors are under the negative control by the PI3Kinase/AKT pathway and other protein kinases [50,51,63].”
• Off the beaten pathway: the complex cross talk between Notch and NF-κB (2008, background): “Hu MC, Lee DF, Xia W, et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.”
• FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. (2011, background): “S644 is targeted by IKKb and this phosphorylation inhibits FoxO3 function by increasing its nuclear exclusion and degradation [113,114].”
• Persistently-activated Stat3 maintains constitutive NF-κB activity in tumors (2009, unknown): “Nevertheless, a critical role of IKK and many of its activators, including TNFa, in tumor initiation by tissue damage/inflammation and in chronic inflammation-associated cancer has been well documented (Hu et al., 2004; Karin and Greten, 2005; Naugler et al., 2007).”