A microRNA component of the p53 tumour suppressor network

By Lin He, Xingyue He, Lee P. Lim, E. Stanchina, Zhenyu Xuan, Yu Liang, W. Xue, Lars Zender, Jill Magnus, Dana Ridzon and 6 more. Nature, 2007

2,843 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/84406551ab5d6cc9ad8833afa848fe154af1ce72

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Citations in the corpus

Development of microRNA therapeutics is coming of age (2014, neutral): “This family comprises three members, miR-34a, -34b and 34c, and based on the shared seed sequence, they are predicted to control an overlapping set of target mRNAs and are, thus, likely to be functionally redundant (He et al , 2007).”
Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (2008, background): “He and colleagues found significant enrichment of cell cycle genes (based on gene ontology classification) among the genes down-regulated by miR34a, miR-34b, or miR-34c in four cancer cell lines (15).”
miR-19 is a key oncogenic component of mir-17-92. (2009, background): “Multiple miRNAs were subsequently identified to promote or suppress oncogenesis, presumably by modulating gene expression in the oncogenic and tumor suppressor networks (He et al. 2005, 2007a; Johnson et al. 2005; Kumar et al. 2008; Kota et al. 2009).”
MicroRNAs in stress signaling and human disease (2012, background): “…the miR-34a and miR-34b/miR-34c transcription units which then are able to mediate some aspects of the cellular response to p53 activation, including cell-cycle arrest and apoptosis (Bommer et al., 2007; Chang et al., 2007; He et al., 2007; Raver-Shapira et al., 2007; Tarasov et al., 2007).”
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008, methodology): “The analysis was performed on RNA samples harvested at 6 and 24 hours posttransfection, consistent with the time frames commonly used for this type of analysis ( 18 , 36, 37).”