Glutathione peroxidases.

By R. Brigelius-Flohé, M. Maiorino. Biochimica et Biophysica Acta, 2013

1,946 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Toxicology

View Paper: https://www.semanticscholar.org/paper/842ddaadfd7acfdfc1580b2f8e62811c378b1db2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Nutrition and Dietetics

In Toxicology

Citations in the corpus

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal (2014, background): “We can also see the protective effects of MAPK activation via GSH induction because the activation of the ERK pathway is involved inGCL (the rate-limiting enzyme in de novo glutathione (GSH) synthesis) regulation in rat cells [273] while the JNKpathways appear to be involved in human HBE-1 cells [27”
Selenium in the Environment, Metabolism and Involvement in Body Functions (2013, background): “endoplasmic reticulum and the last of the family of glutathione peroxidases to be discovered [39].”
The Role of Oxidative Stress in Neurodegenerative Diseases (2015, background): “In mammals, there are five different isoforms of selenium-dependent glutathione peroxidases (GPX1-4 and 6) and three nonselenium congeners (GPX 5, 7 and 8) that have cysteine instead of selenocysteine [42].”
Regulation of Ferroptotic Cancer Cell Death by GPX4 (2014, methodology): “GPXs catalyze the reduction of hydrogen peroxide and organic hydroperoxides to water or the corresponding alcohols, using GSH as an essential cofactor (Brigelius-Flohé and Maiorino, 2013).”
Oxidative stress response and Nrf2 signaling in aging. (2015, neutral): “The GPx family consists of 8 members in mammals, GPx1-4 and GPx6 containing selenium, while GPx5, GPx7, and GPx8 are non-selenium proteins [99].”
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “The rate constant of the oxidation step is ~ 10 8 M −1 s −1 , which is among the fastest enzymatic reactions ever determined in biochemical systems (Brigelius-Flohé and Maiorino 2013).”
Ferroptosis: Death by Lipid Peroxidation. (2016, background): “First, GPX4 is the only enzyme that can reduce lipid hydroperoxides within biological membranes [25].”
Drought and Its Consequences to Plants – From Individual to Ecosystem (2013, background): “Most cellular GPXs are tetrameric enzymes with four identical 22 kDa subunits, each con‐ taining a selenocysteine residue in the active site [82].”
Ferroptosis in cancer therapy: a novel approach to reversing drug resistance (2022, background): “GPX4 can catalyze the reduction of lipid peroxides, which plays a vital role in protecting against excessive lipid peroxidation [8].”
13 reasons why the brain is susceptible to oxidative stress (2018, methodology): “preferentially reduces lipid hydroperoxides (ROOH) over H2O2 [130,131].”
Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “In addition, existing data show that several types of GPx (at least eight isoenzymes) and Prxs (six isoenzymes) coexist [14][15].”
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022, background): “Enzymes in the GPx family include GPx1 through 8, each with different expression patterns within the body [39].”