Natural history of mild cognitive impairment in older persons

By David A. Bennett, R. Wilson, Julie A. Schneider, Denis A. Evans, Laurel A. Beckett, N. Aggarwal, Lisa L. Barnes, J. Fox, J. Bach. Neurology, 2002

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OVERVIEW AND FINDINGS FROM THE RELIGIOUS ORDERS STUDY (2012, methodology): “An algorithm uses these decisions to provide diagnoses of MCI and amnestic MCI [29,30].”
Mild cognitive impairment (2006, methodology): “A second problem is that cognitive performance tests are typically used to document cognitive impairment in MCI [21,22].”
Religious Orders Study: Overview and Change in Cognitive and Motor Speed (2004, methodology): “To maintain consistency in these clinical decisions over time and examiners, we developed educationally adjusted cutoff scores for 11 of the cognitive tests based on published data and extensive pilot testing (Bennett et al., 2002), and these data are also provided to the neuropsychologist.”
Religious Orders Study and Rush Memory and Aging Project (2018, background): “Clinical diagnosis of dementia, especially AD dementia, and MCI are documented [87, 88].”
Rate of progression of mild cognitive impairment to dementia – meta‐analysis of 41 robust inception cohort studies (2009, methodology): “Eight studies (three using Mayo definition and five not using Mayo definition) examined the risk of dementia or AD in healthy age comparable controls head-to-head with the risk in individuals with MCI, a total pooled sample of 6713 individuals (39, 44, 56, 65, 67, 71, 73).”