OVERVIEW AND FINDINGS FROM THE RELIGIOUS ORDERS STUDY

By David A. Bennett, Julie A. Schneider, Zoe Arvanitakis, R. Wilson. Current Alzheimer Research, 2012

669 citations recorded by the source corpus.

The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer’s disease (AD). In this manuscript, we summarize the study methods including the study design and describe the clinical evaluation, assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected post-mortem data. The results: 1) review the relation of neuropathologic indices to clinical diagnoses and cognition proximate to death; 2) examine the relation of risk factors to clinical outcomes; 3) examine the relation of risk factors to measures of neuropathology; and 4) summarize additional study findings. We then discuss and contextualize the study findings.

Subfields: Geriatrics and Gerontology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/4c05d4de33fd4add27d47ed78e098e707f2117e9

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In Geriatrics and Gerontology

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Citations in the corpus

• An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease (2016, background): “We focused on brain samples of Caucasian participants from these two prospective cohort studies of aging that include brain donation at the time of death [80].”
• Religious Orders Study and Rush Memory and Aging Project (2018, neutral): “The last review of these studies summarized findings through the end of 2011 [10, 11].”
• An epigenetic biomarker of aging for lifespan and healthspan (2018, methodology): “DNAm PhenoAge measured in dorsolateral prefrontal cortex relates to Alzheimer’s disease and related neuropathologies Using postmortem data from the Religious Order Study (ROS) and the Memory and Aging Project (MAP), we find a moderate/high correlation between chronological age and DNAm PhenoAge (pan”