Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

By A. Ledeboer, E. Sloane, E. Milligan, M. Frank, J. Mahony, S. Maier, Linda R. Watkins. Pain, 2005

680 citations recorded by the source corpus.

Subfields: Neurology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/83b641e51ed80fa53957c7b94af4da84a389e24a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. Jürgen Sandkühler
2. M. Suter
3. R. Ji
4. G. Moalem-Taylor
5. P. Austin
6. Stephen G. Waxman
7. B. Hains
8. Clifford J. Woolf

In Pharmacology

1. Jürgen Sandkühler
2. M. Suter
3. R. Ji
4. G. Moalem-Taylor
5. P. Austin
6. Zhi-qi Zhao
7. Clifford J. Woolf
8. Alban Latremoliere

In Physiology

1. R. Ji
2. Jürgen Sandkühler
3. M. Suter
4. G. Moalem-Taylor
5. P. Austin
6. Stephen G. Waxman
7. B. Hains
8. Zhi-qi Zhao

Citations in the corpus

• Models and mechanisms of hyperalgesia and allodynia. (2009, background): “Spinal cord cells consist of the following: 4) spinal dorsal horn neurons that express the neurokinin I receptor (318, 383, 542, 545, 575, 611), 5) microglia (192, 276, 375, 423, 502, 564, 618), and 6) astrocytes (213, 387, 624).”
• The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. (2010, positive): “Binding of TNF to its receptors in DRGs and in spinal dorsal horn activates nuclear factor-kappa B (NF-κB), which in turn induces transcription of genes encoding pro-inflammatory cytokines and therefore, plays a role in pain facilitation (Ledeboer et al., 2005a; Wei et al., 2007).”
• Minocycline: far beyond an antibiotic (2013, background): “Minocycline’s beneficial effects in these cases are clearly enhanced when it is administered as early as possible, especially during the initiation stage (Ledeboer et al., 2005; Owolabi and Saab, 2006; Mei et al., 2011).”
• Neural mechanism underlying acupuncture analgesia. (2008, background): “…cord glia (microglia and astrocytes) make important contributions to the development and maintenance of inflammatory and neuropathic pain (Deleo et al., 2004; Ledeboer et al., 2005; Ma and Zhao, 2002; Song and Zhao, 2001; Sun et al., 2007a; Watkins et al., 2005, 2007; Zhang et al., 2005c, 2007c).”
• p38 MAPK, microglial signaling, and neuropathic pain (2007, background): “Similarly, a microglial inhibitor minocycline was shown to prevent/delay neuropathic pain, but not to reverse established neuropathic pain [29,30].”
• Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury (2006, methodology): “…has been shown to inhibit inflammatory cytokines, free radicals production, and matrix metalloproteinases (Stirling et al., 2005) and potently downregulates the activity of microglia in vivo (Raghavendra et al., 2003; Hua et al., 2005; Ledeboer et al., 2005 ), followed by 10 ␮l of aCSF flush.”