Mesenchymal Stem Cells Can Be Differentiated Into Endothelial Cells In Vitro

By J. Oswald, S. Boxberger, Birgitte Jørgensen, S. Feldmann, G. Ehninger, M. Bornhäuser, C. Werner. Stem Cells, 2004

1,320 citations recorded by the source corpus.

Subfields: Biomaterials, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/838459f49036759f098a9e3cabd3b53cd22a0a9c

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In Biomaterials

1. Tom Ben-Arye
2. S. Levenberg

In Genetics

1. Tom Ben-Arye
2. S. Levenberg
3. D. Hanahan
4. Lisa M. Coussens

Citations in the corpus

• Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. (2005, background): “Based on this background, we hypothesized that the already recognized paracrine capabilities of bone marrow-derived mesenchymal stem cells, such as VEGF and HGF secretion (23), and their ability to differentiate into cells of endothelial phenotype (26), may hold particular promise in the treatment o”
• The elusive nature and function of mesenchymal stem cells (2011, neutral): “Many studies have further reported mesenchymal stromal cell differentiation into multiple other cell types of mesodermal and non-mesodermal origin, including endothelial cell”
• Ethical and Safety Issues of Stem Cell-Based Therapy (2018, background): “MSCs have the capacity to differentiate into endothelial cells and to create a capillary network [78, 79].”
• ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. (2005, background): “ABCB5 tumor cells also preferentially express CD166, a marker implicated in melanoma metastasis (47) and associated with the physiologic stem cell phenotype (58, 59).”
• Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. (2007, background): “readily expanded in culture, differentiate into a number of cell types in vitro, including EC (27), and are ideal vehicles for cellular gene transfer (29).”
• Mesenchymal Stem Cell Transition to Tumor-Associated Fibroblasts Contributes to Fibrovascular Network Expansion and Tumor Progression (2009, methodology): “a-SMA positivity has been used previously to identify differentiated MSC [44].”
• Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type1 (2008, background): “Recent reports show that MSCs may have the ability to differentiate into other lineage cells in vitro, such as endothelial cells (6, 7), neural cells (8, 9) and hepatocytes (10, 11).”
• Tissue Engineering for Clean Meat Production (2019, background): “Engineered vascularized skeletal muscle tissues, comprised of muscle cells, fibroblasts and ECs were reported to develop inside PLLA-PLGA scaffolds with a pore size of 200–600µm (Shandalov et al., 2015; Perry et al., 2017b).”
• Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, positive): “Although minimal criteria defined by ISCT state that MSCs should show trilineage differentiation into bone, cartilage, and adipose tissues in vitro, it has been shown that under certain culture conditions, MSCs can differentiate into other mesodermal tissues such as skeletal muscle [39], tendon [40]”