Inflammation, atrophy, and gastric cancer.

By J. Fox, Timothy C. Wang. Journal of Clinical Investigation, 2007

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Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease (2009, background): “Clinical and epidemiologic studies have suggested a strong association between chronic infection, inflammation, and cancer [121–124].”
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. (2008, background): “Carriers of IL-1b polymorphisms (IL-1b-511T and IL-1b-31C), which have been linked to enhanced IL-1b production and increased circulating levels of the cytokine in humans, show an increased risk of gastric cancer (El-Omar et al., 2001; Fox and Wang, 2007).”
Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, background): “Although gastric cancer was the leading cause of cancer death in the United States as recently as 1930, with incidence rates in male exceeding 45 per 100,000, a decline in both incidence and mortality, particularly for distal tumors, has been observed in this country over the past 70 years [1,2].”