Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

By Bret R. Williams, Vineet R. Prabhu, K. E. Hunter, Christina M Glazier, C. A. Whittaker, D. Housman, A. Amon. Science, 2008

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Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, positive): “We think this is due, in part, to the striking degree of aneuploidy (altered chromosome number) often found in solid tumors (Figure 1) (Ganem et al., 2007; Torres et al., 2008; Williams et al., 2008).”
Mitotic catastrophe: a mechanism for avoiding genomic instability (2011, positive): “jpg"/> Somatic cells can reach an aneuploid (and hence potentially tumorigenic) state by losing or gaining single chromosome”
Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis (2009, background): “Unlike point mutations that only affect a small number of genes, the gain or loss of a single chromosome alters the transcription of hundreds of genes and has the capacity to disturb a large array of cellular processe”
Genomic and Functional Approaches to Understanding Cancer Aneuploidy (2018, background): “We initially predicted that deletion of chr_3p would not be as anti-proliferative as other aneuploidies, as it is thought to be an early event in lung tumorigenesis (Hung et al., 1995; Wistuba et al., 2000).”