Biofilms and device-associated infections.

By R. Donlan. Emerging Infectious Diseases, 2001

1,533 citations recorded by the source corpus.

Microorganisms commonly attach to living and nonliving surfaces, including those of indwelling medical devices, and form biofilms made up of extracellular polymers. In this state, microorganisms are highly resistant to antimicrobial treatment and are tenaciously bound to the surface. To better understand and control biofilms on indwelling medical devices, researchers should develop reliable sampling and measurement techniques, investigate the role of biofilms in antimicrobial drug resistance, and establish the link between biofilm contamination and patient infection.

Subfields: Endocrinology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/82b37cd57b01b9cbe98a3a03feefc12866b9c8a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. R. Vasudevan
2. M. Otto
3. J. López-Ribot
4. G. Ramage
5. Derek P. Thomas
6. S. Saville
7. R. Darouiche
8. E. Kojic

In Infectious Diseases

1. R. Vasudevan
2. J. López-Ribot
3. S. Saville
4. G. Ramage
5. E. Kojic
6. M. Otto
7. R. Darouiche
8. G. Donelli

In Molecular Biology

1. R. Vasudevan
2. J. López-Ribot
3. S. Saville
4. G. Ramage
5. M. Otto
6. Derek P. Thomas
7. R. Darouiche
8. E. Kojic

Citations in the corpus

• Staphylococcal biofilms (2018, background): “The source can be the skin or other colonized body sites of the patient or the health care personnel (14).”
• Biofilm formation by Staphylococcus aureus on food contact surfaces: Relationship with temperature and cell surface hydrophobicity (2015, background): “…to form biofilms on materials commonly used in the food sector, such as the stainless steel, glass, rubber, polycarbonate, polyurethane, polystyrene, polypropylene, titanium, aluminum, and ceramic (Donlan, 2001; Hamadi et al., 2014; Sim~oes et al., 2010; V azquez-S anchez, Habimana, & Holck, 2013).”
• Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis (2008, background): “Although several control measures for the prevention of biofilm formation on catheters have been examined, no single biosurface, including silicone, polyurethane, composite biomaterials, or hydrogel-coated materials has been shown to be effective in preventing colonization due to the development of ”
• The relationship between the nanostructure of titanium surfaces and bacterial attachment. (2010, background): “Infection has been reported on an array of implantable devices including central venous catheters and needleless connectors, endotracheal tubes, intrauterine devices, mechanical heart valves, pacemakers, peritoneal dialysis catheters, tympanostomy tubes, voice prostheses, orthopedic joint prosthetic”
• Candida Infections of Medical Devices (2004, background): “Organisms in biofilms behave differently from freely suspended microbes and have been shown to be relatively refractory to medical therapy (28, 29, 90).”
• Candida Biofilms: an Update (2005, background): “This is of particular significance since it is now estimated that a significant proportion of all human microbial infections involve biofilm formation (20, 22, 25, 26, 29, 48).”
• Biofilms: Microbial Cities of Scientific Significance (2014, background): “The biofilm infection among the patients with urinary catheters relies on the duration of usage of these devices as longer duration enhances bacterial growth [116].”
• Understanding bacterial biofilms: From definition to treatment strategies (2023, background): “When microbial cells irreversibly adhere to the surface of a medical device and produce EPS to form a biofilm, the rate of growth and development is influenced by the flow rate, nutrient content, antimicrobial concentration, ambient temperature, and pH (Donlan, 2001).”
• Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. (2012, background): “Catheters, like other medical devices, can serve as a substrate for Candida biofilm infection, which exhibits a drug-resistant phenotype [60, 61], necessitating biofilm extirpation for treatment success [62, 63].”
• Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control. (2015, background): “However, there are features of the microbial cell surface that promote the attachment process to the surface, including flagella, pili, fimbriae and glycocalyx (Donlan, 2001).”
• Biofilms: Microbial Life on Surfaces (2002, background): “A spectrum of indwelling medical devices or other devices used in the healthcare environment have been shown to harbor biofilms, resulting in measurable rates of device-associated infections (74).”