Rapid Translocation of Nanoparticles from the Lung Airspaces to the Body
By Hak Soo Choi, Yoshitomo Ashitate, Jeong Heon Lee, Soon Hee Kim, Aya Matsui, N. Insin, Moungi G. Bawendi, Manuela Semmler-Behnke, John V. Frangioni, A. Tsuda. Nature Biotechnology, 2010
607 citations recorded by the source corpus.
Nano-size particles show promise for pulmonary drug delivery, yet their behavior after deposition in the lung remains poorly understood. In this study, a series of near-infrared (NIR) fluorescent nanoparticles were systematically varied in chemical composition, shape, size and surface charge, and their biodistribution and elimination were quantified in rat models after lung instillation. We demonstrate that nanoparticles with hydrodynamic diameter (HD) less than ≈34 nm and a noncationic surface charge translocate rapidly from the lung to mediastinal lymph nodes. Nanoparticles of HD < 6 nm can traffic rapidly from the lungs to lymph nodes and the bloodstream, and then be subsequently cleared by the kidneys. We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis.
Subfields: Electrical and Electronic Engineering, Health, Toxicology and Mutagenesis, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/8298ca4b60b0030da6680749d4bcf12893484f27
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
Citations in the corpus
- Effect of gold nanoparticle aggregation on cell uptake and toxicity. (2011, background): “ance via the kidney was dependent upon size.(11,12) When working with nanoparticles, it is always crucial to quantify the morphology,”
- The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “, pulmonary [19], oral [20]), the most reproducible way to deliver them is usually by peripheral intravenous injection.”