Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage

By J. Gorski, Tiffany Talley, M. Qiu, Luis Puelles, John L. Rubenstein, K. Jones. Journal of Neuroscience, 2002

1,360 citations recorded by the source corpus.

Subfields: Cell Biology, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8236dba1f3a759c24481f4b7f7c2eb91576bbe49

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Citations in the corpus

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis (2011, background): “However, gene markers for the ventral pallium can identify the lateral and basomedial subregions of the blAMY: Tbr-1 Dbx-1, Lhx2/9, and Lmo3 (Remedios et al., 2004), although some cells express the lateral pallial marker emx1 (Gorski et al., 2002), which may represent migrated cells.”
Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage (2005, background): “In contrast, cell fate mapping using Emx1-Cre transgenic mice suggests that many OLs in the cortex are generated locall”
Area patterning of the mammalian cortex. (2007, background): “Most neocortical neurons, including all glutamatergic neuronsof the corticalplate (CP), fromwhich the six layers of the neocortex will differentiate, and the subplate (SP), are of anEmx1 lineage (Gorski et al., 2002).”
A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb (2008, background): “, 2002), whereas glutamatergic neurons arise from the dorsal telencephalon (Gorski et al., 2002; Malatesta et al., 2003; Kroll and O’Leary, 2005).”
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells (2011, background): “Cerebral cortex-specific deletion of Pals1 was achieved by crossing mice with a conditional Pals1 allele (Pals1loxP/loxP) (Kim et al., 2010) with mice carrying Emx1promoter-driven Cre recombinase (Emx1Cre+/ ) (Gorski et al., 2002).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, methodology): “For experiments in the embryonic and postnatal day 0 forebrain, we used the previously described mouse lines Emx1, β-catenin (28, 29).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “After E18, yet another wave of cortical oligodendrocytes arise, this time from Emx1-expressing precursor cells presumably from dorsal cortex itself (Gorski et al. 2002, Kessaris et al. 2006).”
Driving opposing behaviors with ensembles of piriform neurons. (2011, background): “Injection of this virus into the piriform cortex of Emx1-IRES-Cre mice in which Cre recombinase is restricted to excitatory neurons (Gorski et al., 2002), resulted in ChR2 expression in pyramidal neurons but not inhibitory interneurons (Figure 1B).”
Origins of Cortical Interneuron Subtypes (2004, background): “Previous studies in rodents have indicated that most projection neurons derive from the dorsal, pallial portion of the telencephalon, whereas most cortical interneurons derive from the telencephalic pallidum (Anderson et al., 1997, 2001; Gorski et al., 2002).”