NF-κB1 p105 Negatively Regulates TPL-2 MEK Kinase Activity

By S. Beinke, J. Deka, V. Lang, M. Belich, Philip A. Walker, Steven Howell, S. Smerdon, S. Gamblin, S. Ley. Molecular and Cellular Biology, 2003

121 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8236820df0bb97f44fe082e72a96b5dcbe177816

How researchers see this paper

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In Cancer Research

1. N. Perkins
2. Y. Ben‐Neriah
3. M. Karin

In Molecular Biology

1. N. Perkins

Citations in the corpus

• Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway (2006, background): “The Tpl2 (Cot) kinase, which regulates MAP kinase pathway signaling, is found bound to a small portion of the cellular pool of p105 (Beinke et al., 2003; Waterfield et al., 2004).”
• The Regulation of NF-κB Subunits by Phosphorylation (2016, background): “Free Tpl2 phosphorylates and activates MEK1/2 and triggers a cascade of MAP kinase activity including ERK1/2 [21,22].”
• Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells (2006, background): “S2 ), similarly to its localization in gastric epithelial cell”