Hydrogen sulphide and its therapeutic potential
By C. Szabó. Nature reviews. Drug discovery, 2007
1,846 citations recorded by the source corpus.
Subfields: Biochemistry, Endocrine and Autonomic Systems, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/8154968138308b629ab5d5e6bf5ab5373cb09e41
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In Biochemistry
In Endocrine and Autonomic Systems
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Citations in the corpus
- Ischemia and reperfusion—from mechanism to translation (2011, background): “H 2 S has also been reported to have therapeutic effects in animal models of ischemia and reperfusio”
- Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide (2008, background): “To determine whether the vasodepressor activity of GYY4137 in anesthetized rats translates into an antihypertensive effect, we further observed that (1) acute GYY4137 (but not NaHS) administration reduced the hypertensive effect of L-NAME in the anesthetized rat and (2) chronic GYY4137 administratio”
- Hydrogen sulfide-linked sulfhydration of NF-κB mediates its anti-apoptotic actions (2012, background): “CSE knockout (CSE / ) mice display hypertension and a major decrease in endothelial-derived relaxed factor activity, establishing H2S as an important vasorelaxant (Szabó, 2007; Yang et al., 2008).”
- H2S Signals Through Protein S-Sulfhydration (2009, background): “Recent evidence indicates that hydrogen sulfide (H2S) also acts as a messenger to elicit hibernation states (2), inhibit insulin signaling (3), and regulate inflammation (4) and blood vessel caliber (5).”
- Redox chemistry of biological thiols (2010, background): “Its medical and therapeutic potential is attracting considerable interest [214].”
- H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure. (2010, background): “ALTHOUGH IN GASTROINTESTINAL and nervous systems hydrogen sulfide (H2S) plays a crucial role as a signaling molecule (12, 24), recent studies established that H2S is a cardioprotective gas (4, 21, 27).”