Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide

By Ling-Xia Li, M. Whiteman, Y. Guan, Kay Li Neo, Yvonne Cheng, Shiau-Wei Lee, Yujun Zhao, R. Baskar, Choon‐Hong Tan, P. Moore. Circulation, 2008

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Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure (2017, positive): “GYY4137 has a low, but sustained production of H 2 S, which may be more beneficial for anti-inflammatory purposes and evidence for its use in cardiovascular disease is also mounting.”
Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation (2012, result): “The sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ) inhibited both H2S-induced and NO-induced angiogenesis (Fig.”
Hydrogen sulfide-linked sulfhydration of NF-κB mediates its anti-apoptotic actions (2012, background): “To substantiate the notion that H2S augments promoter interactions while NO blocks them, we treated HEK293 cells with GYY-4137 and GSNO along with TNF-a (10 mg/kg) for 4 hr reveals sulfhydration of Cys38.”
Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “The examples of these slow-releasing compounds are GYY4137 (362) and S-diclofenac (361, 561).”
Hydrogen sulfide: a versatile regulator of environmental stress in plants (2015, background): “It can generate H 2 S slowly and steadily under physiological conditions (Li et al. 2008).”
Hydrogen sulfide and cell signaling. (2011, background): “GYY4137, a novel hydrogen sulfide– releasing molecule, protects against endotoxic shock in the rat.”