Intestinal Integrity and Akkermansia muciniphila, a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

By M. Collado, M. Derrien, E. Isolauri, W. Vos, Willem M. de Vos, S. Salminen. Applied and Environmental Microbiology, 2007

665 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/814ea26d4e08426a3265c0f34fe44038500a1331

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Citations in the corpus

Mucin glycan foraging in the human gut microbiome (2015, background): “…to utilize mucins as sole carbon and nitrogen source, A. muciniphila has since been shown to be a common member of the human gut with a high prevalence and variable abundance, present both in feces and at the mucosal surface (Eckburg et al., 2005; Collado et al., 2007; Derrien et al., 2008).”
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians (2010, result): “This contrasts with the earlier results obtained by Collado et al [42], who demonstrated with FISH and PCR that A. muciniphila counts slightly decline with the age.”
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “muciniphila has been correlated with intestinal integrity, and its relative abundance and absolute numbers are known to increase rapidly with age and specifically after weaning (446).”
The first 1000 cultured species of the human gastrointestinal microbiota (2014, background): “This bacterium is widely distributed and can be detected in fecal material of humans of all age groups (Collado et al., 2007), and although its abundance varies between subjects, it is probably one of the members of the core microbiota.”
The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract (2007, methodology): “Optimal discrimination between the 50 strains (5) and A.”
Akkermansia muciniphila is a promising probiotic (2019, background): “Previous phylogenetic and metagenomic studies based on hundreds of subjects have found that A. muciniphila is one of the top 20 most abundant species detectable in the human gut (Collado et al., 2007, 2012; Qin et al., 2010; Arumugam et al., 2011; Thomas et al., 2014; Drell et al., 2015).”
Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance (2013, background): “As a mucin-degrading bacterium, Akkermansia muciniphila has been widely identified in the intestinal tract and considerable efforts have been made to explore its relationship with human health [25].”
Microbes inside—from diversity to function: the case of Akkermansia (2012, background): “Remarkably, A. muciniphila is a common inhabitant of the intestine of a broad range of animals that has previously been overlooked because of its inconspicuous cell morphology, small size and specific carbon source requirements (Derrien et al., 2004, 2008; Collado et al., 2007).”
Decreased Bacterial Diversity Characterizes an Altered Gut Microbiota in Psoriatic Arthritis and Resembles Dysbiosis of Inflammatory Bowel Disease (2015, background): “Akkermansia is detectable in the majority of healthy subjects (25) and is an important component in 2 of 3 recently described human gut enterotypes (26).”
The Impact of Diet and Lifestyle on Gut Microbiota and Human Health (2014, background): “layer of individuals with IBD [137,138], could contribute to tissue inflammation by weakening the barrier.”
Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. (2008, methodology): “For characterization of fecal microbiota PCR primers were used to target the Bifidobacterium genus group (19), the Bacteroides fragilis group (18), Staphylococcus aureus (20), and Akkermansia muciniphila (21).”
Meta-analyses of human gut microbes associated with obesity and IBD (2014, background): “sible for causing inappropriate immune responses in the host [47–49], as well as opening up niches for occupation by invasive or pro-inflammatory species.”