Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain

By Frederico A. C. Azevedo, Ludmila R.B. Carvalho, Lea Teneholz Grinberg, J. Farfel, R. E. Ferretti, R. Leite, W. J. Filho, Roberto Lent, S. Herculano‐Houzel. The Journal of comparative neurology, 2009

2,197 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/8144a2a93531af58c87418054380aa31d14fd763

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Physiology

Citations in the corpus

Revised Estimates for the Number of Human and Bacteria Cells in the Body (2016, background): “However, a recent analysis [28] revisits this value and, after analyzing the variation across brain regions, concludes that the ratio is close to 1:1.”
Big Data for Health (2015, background): “BRAIN initiative [122].”
Finding a roadmap to achieve large neuromorphic hardware systems (2013, background): “Estimates of the number of neurons in the human brain are between 10 11 and 10 12 (Williams and Herrup, 1988; Mead, 1990; Azevedo et al., 2009), although most recent data leans toward 10 11 (Azevedo et al., 2009).”
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2020, background): “The cerebral cortex occupies a large portion of the mammalian brain (Azevedo et al., 2009) and is uniquely situated to execute multiple functions, from sensory perception and generation of voluntary behavior to emotion, cognition, learning and memory.”
Development and Evolution of the Human Neocortex (2011, positive): “5 kg) and neuron number (86 billion) (Azevedo et al., 2009; reviewed by Herculano-Houzel, 2009), this ratio does not deviate from what would be expected from a primate brain of similar mass, implying that, in terms of brain size and density, the human brain conforms to a scaled-up primate brain.”
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics (2011, background): “and the grey matter of the cortex, which contains the majority of deposited amyloid-β, comprises 42% of the weight of the brai”
Physiology of Astroglia. (2018, neutral): “A recently developed method of isotopic fractionation [which was validated by unbiased stereological techniques for humans and macaque monkeys (85)]shows that total numbers of neurons and glia in the human brain are roughly the same, with substantial variations between different brain regions (79, 6”
Parcellations and Connectivity Patterns in Human and Macaque Cerebral Cortex (2016, background): “Human cortex has about fourfold more neurons (~8 billion/hemisphere) and ninefold greater surface area (~973 88 cm2/hemisphere), equivalent to a pair of 35 cm pizzas (Azevedo et al. 2009; Van Essen et al. 2012c).”