Organization and execution of the epithelial polarity programme
By E. Rodriguez-Boulan, I. Macara. Nature reviews. Molecular cell biology, 2014
679 citations recorded by the source corpus.
Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial transport functions and cytoplasmic polarity to generate different cell progenies for tissue morphogenesis. The establishment and maintenance of a polarized epithelial cell with apical, basolateral and ciliary surface domains is guided by an epithelial polarity programme (EPP) that is controlled by a network of protein and lipid regulators. The EPP is organized in response to extracellular cues and is executed through the establishment of an apical–basal axis, intercellular junctions, epithelial-specific cytoskeletal rearrangements and a polarized trafficking machinery. Recent studies have provided insight into the interactions of the EPP with the polarized trafficking machinery and how these regulate epithelial polarization and depolarization.
Subfields: Genetics, Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/8114813bc5c7f452ad194a72c54324979575478f
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In Genetics
In Molecular Biology
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- Asier González González
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In Plant Science
Citations in the corpus
- The Hippo Pathway: Biology and Pathophysiology. (2019, background): “Epithelial cells form cell–cell junctions through TJs, AJs, and desmosomes (107).”