De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.

By K. D. de Visser, Lidiya V Korets, Lisa M. Coussens. Cancer Cell, 2005

819 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8100659349202ee8f93468a29a403b6303992025

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Citations in the corpus

The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “For instance, B lymphocyte-derived soluble mediators have been shown to be required for MC accumulation in a mouse model for skin cance”
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. (2005, background): “... of the RIP1-Tag2, Rag1�/� mice extends upon these previous studies, demonstrating that mature B and T lymphocytes cannot be factors in pancreatic islet tumorigenesis in RIP-Tag2 mice, either as enhancers or antagonists, since their absence neither attenuates nor accelerates tumorigenesis, in con”
Macrophage activation by endogenous danger signals (2008, background): “While it is clear that in some experimental systems antibodies to tumour-associated antigens can be protective, there are also a number of instances in which antibody depletion actually leads to reduced tumour growth [144,145].”
Cancer-related inflammation (2008, background): “These antibodies then function as a 'remote-control system', binding to unidentified molecules in the extracellular matrix and thereby activating inflammatory responses that promote cancer progressio”
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses (2009, neutral): “In a transgenic model of skin carcinogenesis driven by keratinocyte-specific expression of the human papillomavirus-16 E6 and E7 oncogenes, B lymphocytes proved to be major promoters of tumor formatio”
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm (2010, background): “The pathway involves T cell–dependent autoantibody production by B cells directed against an extracellular matrix component, leading to the recruitment of mononuclear phagocytes and skewing of TAMs by immune complexes in an M2-like directio”
Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “Accumulating evidence indicates that B cells promote and support tumor growth; for example, using a transgenic mouse model of epithelial carcinogenesis, Coussens and colleagues (de Visser et al. 2005) demonstrated that the lack of mature B cells decreases tumor progression.”