Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration

By M. Rausch, S. Weisberg, P. Vardhana, DV Tortoriello. International Journal of Obesity, 2008

594 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Adipose tissue plasticity in health and disease (2022, background): “CD8 effector T cells infiltrate adipose tissue at early stages of obesity development, stimulating macrophage recruitment and inflammation (Nishimura et al., 2009; Rausch et al., 2008).”
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “Consequently, obesity-associated adipose tissue hypoxia has been demonstrated by several groups in human adipose tissue (3, 13, 24) and in rodent adipose tissue (20, 37, 53).”
The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases (2016, background): “Macrophages also sense the unfavourable conditions within human body including hypoxic and metabolic stresses where response of host defense and immune regulation are triggered [4, 5].”