Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

By Tayeba Khan, E. Muise, P. Iyengar, Zhao V. Wang, M. Chandalia, N. Abate, Bei B. Zhang, P. Bonaldo, S. Chua, P. Scherer. Molecular and Cellular Biology, 2008

971 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/001476152ea5dfbb947446bed4559cf2e483e14f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Jerrold M. Olefsky
2. Alan R. Saltiel
3. A. Chait
4. Laura J. den Hartigh
5. Hannele Yki-Järvinen
6. P. Scherer
7. S. Klein
8. Amalia Gastaldelli

In Physiology

1. Jerrold M. Olefsky
2. A. Chait
3. Laura J. den Hartigh
4. Alan R. Saltiel
5. P. Scherer
6. Hannele Yki-Järvinen
7. Amalia Gastaldelli
8. Karine Clément

In Surgery

1. P. Scherer
2. Jerrold M. Olefsky
3. Alan R. Saltiel
4. A. Chait
5. Laura J. den Hartigh

Citations in the corpus

• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “To date, most studies of WAT ECM function have centered around collagen, which can form a scaffold that constrains adipocyte expansion due to mechanical stress (391, 392, 395).”
• Inflammatory mechanisms linking obesity and metabolic disease (2017, background): “Indeed, adipocyte knockout of collagen genes (21) or the collagenases that degrade collagen, particularly MMP14, has a major impact on lipid synthesis, storage, and energy metabolism (22).”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “In addition, it has been proposed that adipose tissue fibrosis in obese subjects caused by excess deposition of collagen, including type VI, leads to adipose tissue inflammation by triggering the infiltration of immune cells, such as macrophages, neutrophils, and lymphocytes (87, 182, 183).”
• Why Does Obesity Cause Diabetes? (2022, background): “, 2012), which stimulates adipose tissue fibrogenesis and macrophage chemotaxis (Halberg et al., 2009; Khan et al., 2009) and can suppress adipose tissue branchedchain amino acid catabolism, thereby increasing plasma branched-chain amino acid concentrations (Bianchi et al.”
• Fibrosis and Adipose Tissue Dysfunction (2013, background): “Adipocytes are surrounded by a network of extracellular matrix proteins that serve as mechanical support and that respond to different signaling events (Khan et al., 2009).”