Inflammatory mechanisms linking obesity and metabolic disease

By Alan R. Saltiel, Jerrold M. Olefsky. Journal of Clinical Investigation, 2017

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How researchers see this paper

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Unraveling the Complex Interplay Between T Cell Metabolism and Function (2018, background): “There is a growing appreciation that aberrant immune cell function underlies numerous pathologies that, even 10 years ago, were not linked to an immune component, as exemplified by Alzheimer disease (1, 2) and obesity (3, 4).”
Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments (2023, background): “Frontiers in Endocrinology 08 system that impacts metabolic balance, resulting in tissue damage via increased fibrosis and necrosis at the same time (79).”
Metabolic Instruction of Immunity (2017, positive): “For example, circulating IL-6 levels are elevated in patients with chronic inflammation, which can modulate fatty acid metabolism and cell survival in many tissues including skeletal muscle, hepatocytes, the central nervous system (CNS), and neuroendocrine system (Saltiel and Olefsky, 2017).”