Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells.

By E. Nagoshi, C. Saini, Christoph Bauer, T. Laroche, F. Naef, U. Schibler. Cell, 2004

1,017 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/80c5e7cdd2479226a41a00ae42dade8b80ee2870

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

In Plant Science

Citations in the corpus

Harmonics of Circadian Gene Transcription in Mammals (2009, methodology): “We applied this method to the study of gene transcription in the liver , an organ system that receives and integrates systemic cues, as well as synchronized NIH3T3 and U2OS cells, conventional models of the autonomous cellular oscillator [22,23].”
Molecular components of the mammalian circadian clock. (2006, background): “If viewed at the single-cell level, the molecular clockwork of transcription and translation can be observed as autonomous single-cell oscillators (Nagoshi et al. 2004; Welsh et al. 2004).”
The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “As mentioned above, cell division, during which the cellular contents are cut approximately in half, does not abrogate oscillator function but causes only relatively modest phase shifts (Figure 4c) (107).”
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, methodology): “for High-Magnitude Bmal1 Expression In order to examine whether SIRT1 might influence circadian gene expression, we followed real-time bioluminescence recordings of a Bmal1-luciferase reporter whose expression is driven by the Bmal1 promoter (Nagoshi et al., 2004).”
Stochastic gene expression and its consequences (2008, background): “…plays a key role in the generation of circadian rhythms, and single-cell experiments have shown the performance of the clock in individual mammalian cells can be rather poor, with strikingly variable periods observed both in culture (Nagoshi et al., 2004) and in whole organisms (Liu et al., 1997).”
Circadian rhythm disturbances in depression (2008, background): “Recent studies have shown that circadian oscillators can also be found in mammalian peripheral tissues, such as the liver (Matsuo et al., 2003), kidney (reviewed in Ikonomov et al., 1998), heart (Stoynev et al., 1996), and fibroblasts (Nagoshi et al., 2004; Yagita et al., 2001).”
Suprachiasmatic Nucleus: Cell Autonomy and Network Properties (2010, background): “In the case of cultured fibroblasts, the damping is due to desynchrony among cells (6, 89).”
CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “The cell-autonomous clock is ubiquitous, and almost every cell in the body contains a circadian clock (Balsalobre et al. 1998, Nagoshi et al. 2004, Welsh et al. 2004, Yoo et al. 2004).”
Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors (2005, background): “…a major role in orchestrating rhythmicity throughout the organism, most tissues and even isolated cells possess their own and ostensibly similar circadian clocks (Balsalobre et al., 1998; Yamazaki et al., 2000; Nagoshi et al., 2004; Welsh et al., 2004; Yoo et al., 2004; Carr and Whitmore, 2005).”
System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock (2007, methodology): “Cultures were maintained at 37 8C in a light-tight incubator, and bioluminescence was monitored continuously using Hamamatsu photomultiplier tubes (PMT; Hamamatsu, Hamamatsu City, Japan) [31].”