Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons
By Jeffrey C. Magee, E. Cook. Nature Neuroscience, 2000
653 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/804e70b98743300f08c768926f14b5a650eab7b9
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
- Wulfram Gerstner
- Michael Häusser
- Henry Markram
- Per Jesper Sjöström
- Nelson Spruston
- Arnd Roth
- Idan Segev
- E. Rancz
In Cognitive Neuroscience
- Wulfram Gerstner
- Michael Häusser
- Henry Markram
- Per Jesper Sjöström
- Arnd Roth
- Idan Segev
- Nelson Spruston
- E. Rancz
Citations in the corpus
- Dendritic excitability and synaptic plasticity. (2008, positive): “The “democracy deficit” of pyramidal neurons is in part compensated by distance-dependent scaling of synaptic conductances in the apical dendrite of CA1 neurons (467).”
- Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties (2011, background): “This distribution of Ih ensured that all our models exhibited key subthreshold properties of L5b PCs such as Ih related effects on EPSP summation [40–43], as well as a resting membrane potential gradient along the apical tree, with a slope of 10 mV/mm [7,13].”
- Molecular and Cellular Biophysics: Index (2006, background): “The pyramidal cells of the hippocampus compensate for 430 CABLE THEORY this attenuation by having higher receptor densities at distal locations so that activating synapses at those sites produces larger currents (Magee and Cook, 2000).”
- Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. (2006, background): “Dual recordings from CA1 neurons show that distal apical trunk mEPSP mean amplitude appears w20% larger at the soma because of the loss of small amplitude events into the noise (Magee and Cook, 2000).”
- Computing the Local Field Potential (LFP) from Integrate-and-Fire Network Models (2015, background): “, equal impact of synaptic inputs at the site of dendritic integration [49,50]).”
- Pyramidal neurons: dendritic structure and synaptic integration (2008, background): “Evidence for such 'synaptic scaling' has been identified at some but not all synapses in CA1 pyramidal neuron”
- Hyperpolarization-activated cation channels: from genes to function. (2009, neutral): “In addition, it has been shown that the density of AMPA glutamate receptors is increased in distal dendrites of several neurons, increasing the strength of distal synapses (10, 242, 352).”
- The high-conductance state of neocortical neurons in vivo (2003, background): “Another possible solution is to rescale synaptic conductances in proportion to the distance from the soma, so that all synapses evoke roughly equivalent somatic EPSPs, as observed in hippocampal pyramidal neuron”