Organization and function of the 3D genome

By B. Bonev, Giacomo Cavalli. Nature reviews genetics, 2016

989 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/803c2fbd967512a1bd4edfaa9fc8623a429509be

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In Molecular Biology

Citations in the corpus

Chromatin organization by an interplay of loop extrusion and compartmental segregation (2017, background): “1A), which indicates that chromatin of a given type preferentially interacts with other loci of the same type (3, 4).”
Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III (2020, background): “Previous studies showed that structural factors such as CTCF and Cohesinmediated chromatin interactions create frameworks for loop domains and constrain high-frequency chromatin interactions within them [2, 3, 72, 73].”
Galaxy HiCExplorer 3: a web server for reproducible Hi-C, capture Hi-C and single-cell Hi-C data analysis, quality control and visualization (2020, background): “For a review on the abilities and current developments of Hi-C and related techniques, the reviews of McCord et al. (13), Kempfer and Pombo (14) or Bonev and Cavalli (15) are recommended.”
Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization (2017, neutral): “When reported on linear genomic maps, the alternating pattern of compartment types forms a domain-wide arrangement that aligns strikingly with regional chromatin states (Bickmore and van Steensel, 2013; Bonev and Cavalli, 2016).”
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting. (2017, positive): “TADs interact to form active and inactive chromosome compartments, which organize into chromosome territories (for reviews, see Bonev and Cavalli, 2016; Entrevan et al., 2016; Schwartz and Cavalli, 2017).”
YY1 Is a Structural Regulator of Enhancer-Promoter Loops (2017, positive): “…and regulate transcription from the promoters of nearby or distant genes through physical contacts that involve looping of DNA between enhancers and promoters (Bonev and Cavalli, 2016; Fraser et al., 2015; Heard and Bickmore, 2007; de Laat and Duboule, 2013; Pombo and Dillon, 2015; Spitz, 2016).”
p-Adic mathematical physics: the first 30 years (2017, neutral): “This hierarchical organization was observed experimentally [230, 231].”